Synthesis and biophysical analysis of modified thymine-containing DNA oligonucleotides.
نویسندگان
چکیده
We report the synthesis of a 5-formyl-2'-deoxyuridine (5fU) phosphoramidite and the preparation of oligonucleotides comprising all known, naturally observed eukaryotic thymidine modifications. Biophysical characterization of the synthetic oligonucleotides indicates that 5fU, but not the other T-derivatives, can alter DNA structures.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 53 8 شماره
صفحات -
تاریخ انتشار 2017